DBCO-PEG24-amido-PEG24-DSPE represents a polyPEG lipid with a terminal DBCO group that reacts azides via copper-free catalyzed click chemistry and DSPE, which is approved by the FDA for medical applications. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG linkers increase water solubility for effective drug delivery.
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