Val-Cit-PAB-MMAE is a derivatized linker-payload that can be used in the creation of antibody-drug conjugates (ADCs). It contains a cathepsin-cleavable Val-Ala dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The azide moiety can react with alkyne, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. The PEG spacer enhances the water-solubility of the compound and may aid in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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