Aminooxy-PEG2-SPDB-DM4 represents a linker-payload consisting of a terminal aminooxy that reacts with aldehydes or ketones to form a stable oxime linkage and maytansine-derived payload DM4, known for its tubulin-inhibiting properties. These groups are linked via an SPDB linker, resulting in a highly effective treatment with strong anti-tumor capabilities. It is suitable to be conjugated into antibody-drug conjugates (ADCs). The PEG spacer imparts hydrophilicity and is involved in assisting in the optimization of DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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