N-(acid-PEG4)-N-bis(PEG4-azide) is a branched linker containing two azides and a terminal caboxylic group. The azide group is reactive towards terminal alkynes and strained cyclooctynes using click chemistry. The terminal carboxylic acid group can conjugate with amine molecules in the presence of activators such HATU. PEG linkers provide high aqueous solubility, and altering PEG length can alter DMPK.
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