Beta-Sitosterol, a prominent plant phytosterol, shares similarities with cholesterol, as it can undergo oxidation, forming beta-sitosterol oxides. As a C-24 alkyl derivative, its tail and body variations impact size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs). Consequently, it shows promise in improving gene transfection capabilities.
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