Biotin-PEG11-TCO is a PEG linker containing a biotin group and a trans-cyclooctene (TCO) functional group. Biotin is useful for affinity-based applications such as pull-down assays while TCO is a click chemistry handle that quickly reacts with tetrazine groups on target molecules. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.
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