Mal-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a maleimide, a Val-Cit dipeptide, a PAB group, and an MMAE toxin. Maleimide is a thiol-specific covalent linker which is used to conjugate cysteine residues in proteins while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism.
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