4-(4-azidobutylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione is a PROTAC linker featuring pomalidomide with an N-butyl azide. Pomalidomide recruits E3 ligase for the ubiquitinylation of target proteins. Meanwhile, azide groups might be used in click chemistry to react with terminal alkynes or strained cyclooctynes.
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