6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a methyltetrazine. Thalidomide is a ligand for E3 ligase, which marks proteins for proteolysis. Meanwhile, the methyltetrazine is a click chemistry handle used to form bonds with TCO groups on target molecules.
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