Thalidomide-NH-PEG4-COOH is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a carboxylic acid. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. The carboxylic acid is reactive towards amines and alcohols with the use of coupling reagents such as EDC or HATU.
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