DBCO-PEG8-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB fragment.
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