m-PEG-Vinylsulfone, MW 5,000 is a large PEG linker with a methoxy cap and a vinylsulfone residue. The vinylsulfone group is a thiol-specific covalent ligand which is used for labeling proteins via the amino acid, cysteine. The methoxy cap is a relatively inert structure which allows PEGylation to selectively proceed on the vinylsulfone.
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