Thalidomide-O-PEG8-Amine, HCl salt is a PROTAC linker featuring a thalidomide ligand and a primary amine connected by a PEG chain. Primary amines readily form amides with carboxylic acids in the presence of coupling reagents. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
Usually ships within 24 hours.