Azido-PEG8-diglycoamide-Lys(Boc)-PAB is a PEG labeling reagent featuring an azide, a Val-Lys dipeptide, and a PAB group. Azides are highly reactive in click chemistry with terminal alkynes and strained cyclooctynes while the Val-Lys dipeptide is enzyme cleavable and triggers payload release via an elimination mechanism within the PAB structure. Finally, the ε-amine of the lysine is Boc-protected.
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