Amine-PEG8-Val-Cit-PAB-MMAE

Amine-PEG8-Val-Cit-PAB-MMAE


Amine-PEG8-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Primary amines readily form amides with carboxylic acids in the presence of activator reagents such as HATU or EDC, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Molecular structure of the compound BP-40200
    • Unit
    • Price
    • Qty
    • 1 MG
    • $360.00
    • 5 MG
    • $870.00
    • 10 MG
    • $1280.00

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