NH-bis(PEG8-t-butyl ester) is a bifunctional PEG linker with a pair of t-butyl esters joined together at a secondary amine. The secondary amine can be used as a nucleophile while the t-butyl esters can be deprotected to allow for reactions with nucleophiles such as amines or alcohols. The use of a PEG spacer increases aqueous solubility and will impact the ADME of the final PEG conjugate.
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