Carboxy-Amido-PEG4-t-Boc-N-amido is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. The hydrophilic PEG spacer increases solubility in aqueous media. .
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