DBCO-PEG4-PAB-MMAE is a synthetic antineoplastic agent coupled to an DBCO group by a PEG linker. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (mAB) which directs it toward cancer cells. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG spacer increases solubility in aqueous media.
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