PEI-g(10k)-PEG(5k), 20% PEG ratio is a graft copolymer of branched PEI (bPEI) which is modified with a 5 kDa mPEG along 10% of its residues. bPEI shows variable solubility in water, which is improved through the inclusion of hydrophilic PEG residues. These copolymers can be used to improve drug delivery of oligonucleotides. Altering the MW or % PEG of a PEI copolymer will alter a number of factors crucial to ADME such as size, surface charge, and stability. Finally, PEI-PEG copolymers are easily functionalized along the many primary amines in the PEI structure.
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