Folate-PEG-amine, MW 5,000 is a PEG derivative with folate moiety which can bind to specific receptor on the surface of a broad spectrum of solid tumor cells. Scientists have shown promising results in mediating (site specific) uptake of various drugs by targeting the folate receptor. The terminal amine can react with a variety of functional groups, such as succinimidyl ester (NHS) or carboxylic acid (COOH) in the presence of HATU or EDC.
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