DLin-KC2-DMA

DLin-KC2-DMA

DLin-KC2-DMA is an ionizable lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates. The pKa is 6.7.

Molecular structure of the compound BP-25708
    • Unit
    • Price
    • Qty
    • 25 MG
    • $250.00
    • 50 MG
    • $450.00
    • 100 MG
    • $750.00
    • 250 MG
    • $1500.00

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Product Citations

  1. Liu, H., Vidallon, M. L. P., Trépout, S., Cagnes, M., Yepuri, N. R., Darwish, T., ... & Wang, X. (2025). Mapping Hydration and Nanoarchitecture in mRNA‐Loaded Lipid Nanoparticles Through Small‐Angle Neutron Scattering. Small Structures, e202500636.
    https://onlinelibrary.wiley.com/doi/full/10.1002/sstr.202500636
  2. Shi, P., Liu, H., Refaat, A., Nguyen, H., Nguyen, A., Miao, K., ... & Wang, X. (2025). Innovative γ-Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery.
    https://chemrxiv.org/engage/chemrxiv/article-details/68bfb8ed728bf9025e262993