DBCO-PEG4-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.

Molecular structure of the compound BP-25659
    • Unit
    • Price
    • Qty
    • 10 MG
    • $680.00
    • 25 MG
    • $1350.00
    • 50 MG
    • $1950.00
    • 100 MG
    • $2900.00

Usually ships within 24 hours.

Would you like to inquire about custom quantity?

Product Citations

  1. Danielewicz, Natalia, Francesca Rosato, Jana Tomisch, Jonas Gra?ber, Birgit Wiltschi, Gerald Striedner, Winfried Ro?mer, and Juergen Mairhofer. Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer Therapy.. ACS Omega. 2023
  2. Yang, Q., Chen, H., Ou, C., Zheng, Z., Zhang, X., Liu, Y., ... & Wang, L. X. (2023). Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody–Drug Conjugates. Antibodies, 12(4), 71.