DBCO-PEG4-Val-Cit-PAB-MMAE
DBCO-PEG4-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.

-
Catalog:
BP-25659
-
Name:
DBCO-PEG4-Val-Cit-PAB-MMAE
-
Formula:
C88H128N12O19
-
MW:
1658.1
-
CAS:
2129164-91-4
-
Purity:
98%
-
Ships Within:
24 Hours
-
Storage Condition:
-20°C
-
Solubility:
DMSO, DCM, DMF
-
Shipping:
-
Availability:
In Stock
-
NMR:
View
-
SDS:
View
Product Citations
- Danielewicz, Natalia, Francesca Rosato, Jana Tomisch, Jonas Gra?ber, Birgit Wiltschi, Gerald Striedner, Winfried Ro?mer, and Juergen Mairhofer. Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer Therapy.. ACS Omega. 2023
https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00667 - Yang, Q., Chen, H., Ou, C., Zheng, Z., Zhang, X., Liu, Y., ... & Wang, L. X. (2023). Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody–Drug Conjugates. Antibodies, 12(4), 71.
https://www.mdpi.com/2073-4468/12/4/71