DBCO-PEG4-Val-Cit-PAB-MMAE

DBCO-PEG4-Val-Cit-PAB-MMAE

DBCO-PEG4-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.

Molecular structure of the compound BP-25659
    • Unit
    • Price
    • Qty
    • 10 MG
    • $650.00
    • 25 MG
    • $980.00
    • 50 MG
    • $1600.00
    • 100 MG
    • $2600.00

Usually ships within 24 hours.

Would you like to inquire about custom quantity?
Inquire

Product Citations

  1. Bernstein, Z. J., Gierke, T. R., Dammen-Brower, K., Tzeng, S. Y., Zhu, S., Chen, S. S., ... & Spangler, J. B. (2024). Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants. Journal of Biological Chemistry, 300(12).
    https://www.jbc.org/article/S0021-9258(24)02507-9/fulltext
  2. Chen, F., & Bradbury, M. S. (2025). Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications. Journal of Nanobiotechnology, 23(1), 1-18.
    https://link.springer.com/article/10.1186/s12951-025-03631-4
  3. Danielewicz, Natalia, Francesca Rosato, Jana Tomisch, Jonas Gräber, Birgit Wiltschi, Gerald Striedner, Winfried Römer, and Juergen Mairhofer. Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer Therapy.. ACS Omega. 2023
    https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00667
  4. Nirachonkul, W.; Farrell, M. P.; Tolbert, T. J.; Okonogi, S.; Tima, S.; Anuchapreeda, S.; Chiampanichayakul, S.; Siahaan, T. J. Mislocalisation of FLT3-ITD Receptor Contributes to MV4-11 Leukaemia Cell Resistance to Antibody-Drug Conjugate. Journal of Enzyme Inhibition and Medicinal Chemistry 2026, 41 (1).
    https://doi.org/10.1080/14756366.2026.2638027
  5. Petri, L.; Kovács, Í. K.; Szabó, B.; Imre, T.; Rácz, A.; Chudasama, V.; Szijj, P. A.; Keserű, G. M. Efficiency Landscape of Bioorthogonal Click Reactions Producing Bispecific Antibody Conjugates. Cell Reports Methods 2026, 101416.
    https://doi.org/10.1016/j.crmeth.2026.101416
  6. Ringaci, A., Shih, T. Y., & Grinstaff, M. W. (2025). A Supramolecular Self-assembly Approach to Site-Specific Antibody Conjugates via a Coiled-coil Peptides Platform. bioRxiv, 2025-07.
    https://www.biorxiv.org/content/10.1101/2025.07.21.665979v1.full
  7. Ringaci, A.; Shih, T.-Y.; Grinstaff, M. W. Supramolecular Coiled-Coil Peptide Platform for Site-Specific Antibody Drug Conjugate Engineering. Nature Communications 2026, 17 (1).
    https://doi.org/10.1038/s41467-026-70094-y
  8. Yang, Q., Chen, H., Ou, C., Zheng, Z., Zhang, X., Liu, Y., ... & Wang, L. X. (2023). Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody–Drug Conjugates. Antibodies, 12(4), 71.
    https://www.mdpi.com/2073-4468/12/4/71
  9. Yen-Pang HSU, Sampat L. INGALE. Bisecting-glycan bridged conjugation for producing glycoprotein conjugates. (EP4615513A1)
    https://patents.google.com/patent/EP4615513A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=17