DSPC

DSPC

DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) is a phosphatidylcholine with saturated tails. It has a melting temperature of ~54°C and a cylindrical geometry that allows DSPC molecules to form a lamellar phase, which stabilizes the structure of lipid nanoparticles. DSPC has been used in the mRNA-1273 and BNT162b2 COVID-19 vaccines. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-25623
    • Unit
    • Price
    • Qty
    • 500 MG
    • $140.00
    • 1 G
    • $260.00
    • 5 G
    • $650.00

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Product Citations

  1. Baugh, N. J.; Huang, M. S.; de Paiva Narciso, N.; Bunch, J. A.; Williams, J.; Zhang, D.; Doulames, V. M.; Liu, Y.; Onsongo, R.; Kilian, D.; Navarro, R. S.; Heilshorn, S. C. Lipid Network Crosslinked Hydrogels Control Material Dynamics Across Multiple Length Scales Through Lipid Movement. Nature Communications 2026, 17 (1).
    https://doi.org/10.1038/s41467-026-77268-8
  2. Farzani, T.; Espinoza, N.; Manafi, M. M.; Welch, S. R.; Coleman-McCray, J. D.; Aida-Ficken, V.; Spengler, J. R.; Bergeron, É.; Spiropoulou, C. F.; Borges, C.; Bielecki, K.; Li, L.; Shah, D.; Paye, M.; Rojas, E.; Spector, S. N.; Samani, P.; Hensley, L. E.; Ozonoff, A.; Sabeti, P. C. A Modular MRNA–LNP Vaccine Platform Enables Integrated RNA, Lipid and Antigen Design to Protect against CCHFV. 2026.
    https://doi.org/10.64898/2026.01.17.699915
  3. Hossainy, S., Kang, S., Gómez Medellín, J. E., Alpar, A. T., Refvik, K. C., Ma, Y. Y., ... & Hubbell, J. A. (2025). Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics. Nature Biomedical Engineering, 1-18.
    https://www.nature.com/articles/s41551-025-01469-7
  4. Jeffrey A. Hubbell, Seounghun KANG, Samir HOSSAINY, Stuart ROWAN, Jorge Emiliano GOMEZ MEDELLIN, Anna J. SLEZAK, Aaron ALPAR. Amphiphilic block copolymers, polymersomes, and methods of use. (WO2025145010A1)
    https://patents.google.com/patent/WO2025145010A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=4
  5. Jeffrey A. Hubbell, Seounghun KANG, Samir HOSSAINY, Stuart ROWAN, Jorge Emiliano GOMEZ MEDELLIN, Anna J. SLEZAK, Aaron ALPAR. Amphiphilic block copolymers, polymersomes, and methods of use. (WO2025145010A1)
    https://patents.google.com/patent/WO2025145010A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=4
  6. Kim, B., Seo, H. W., Lee, K., Yong, D., Park, Y. K., Lee, Y., ... & Ryu, C. M. (2024). Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection. Advanced Healthcare Materials, 2403281.
    https://doi.org/10.1002/adhm.202403281
  7. Li, Y., Ambati, S., Meagher, R. B., & Lin, X. (2025). Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model. npj Vaccines, 10(1), 24.
    https://www.nature.com/articles/s41541-025-01079-z
  8. Pascal, P.; Guerriero, G.; Johannes, B.; Grossrieder, T.; Cattaneo, M.; Collado-Lara, G.; Blanken, N.; Oberhuber, I.; Kusch, J.; Supponen, O.; Schuerle, S. The Cocktail Method: Influence of Microbubble Shell Homogeneity on Acoustic Behavior and Stability. Soft Matter 2026, 22 (29), 4881–4893.
    https://doi.org/10.1039/d6sm00286b
  9. Rochman, Y., Kotliar, M., Klingler, A. M., Rochman, M., Alameh, M. G., Melamed, J. R., ... & Rothenberg, M. E. (2025). Allergen-specific mRNA–lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice. The Journal of Clinical Investigation, 135(21).
    https://www.jci.org/articles/view/194080
  10. Shah, S., Ranasinghe, M., Decker, J., Fraser, K., Friedman, A., Wang, Y., ... & Yao, S. (2025). Lipid Nanoparticles with Aptamers Enable Targeted mRNA Delivery to CD4⁺ T Cells. bioRxiv, 2025-09.
    https://www.biorxiv.org/content/10.1101/2025.09.10.675359v1.full
  11. Tae-Gon Cha, Cosmas Giallourakis, Srinivas Chollangi, Zhongxiao WANG. Non-viral circular single-stranded dna systems and uses thereof. (WO2025193723A1)
    https://patents.google.com/patent/WO2025193723A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=1
  12. Xiao, Y.; Chan, C. K. W.; Lee, L. K. C.; Shyngys, M.; Chiu, Y. T. E.; Xue, E. Y.; Lui, K. O.; Chan, H. Y. E.; Leung, S. S. Y.; Yao, X.; Choi, C. H. J. A Worm-like Nucleic Acid Nanostructure for Gene Delivery and Endosomal Escape via ClC3 Ion Exchanger. Science Advances 2026, 12 (10).
    https://doi.org/10.1126/sciadv.adw0891