OTX-015 is a selective BRD2, BRD3, and BRD4 inhibitor and inhibits the binding of BRD2, BRD3, and BRD4 to AcH4. OTX-015 has shown inhibition of BRD2, BRD3, and BRD4 with IC50 values are in the range 92 - 112 nM. OTX 015 displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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