DBCO-PEG12-NHS ester

DBCO-PEG12-NHS ester

DBCO-PEG12-NHS Ester is a monodisperse PEG linker which enable free copper click chemistry with N3 group. NHS ester moiety can react specifically and efficiently with primary amines to form a covalent amide bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-24149
    • Unit
    • Price
    • Qty
    • 25 MG
    • $380.00
    • 50 MG
    • $650.00
    • 100 MG
    • $960.00
    • 250 MG
    • $1850.00

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Product Citations

  1. John T. Wilson, Karan ARORA, Blaise R. KIMMEL, Hayden Michael PAGENDARM. Nanobody vaccine compositions. (WO2025081106A2)
    https://patents.google.com/patent/WO2025081106A2/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=7
  2. John T. Wilson, Karan ARORA, Blaise R. KIMMEL. Nanobody-drug conjugates and methods of preparing thereof. (WO2024107885A1)
    https://patents.google.com/patent/WO2024107885A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=17
  3. Kimmel, B. R., Arora, K., Chada, N. C., Bharti, V., Kwiatkowski, A. J., Finkelstein, J. E., ... & Wilson, J. T. (2025). Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates. Nature Biomedical Engineering, 1-21.
    https://www.nature.com/articles/s41551-025-01400-0
  4. Kimmel, B.R., Arora, K., Chada, N.C. et al. Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates. Nat. Biomed. Eng (2025)
    https://doi.org/10.1038/s41551-025-01400-0
  5. Marple, A. S., Jesmer, A. H., Lake, B. P., Rullo, A. F., & Wylie, R. G. (2023). A Modular Antibody‐Oligomer T Cell Engager for Applications in Local Therapies. Advanced Therapeutics, 6(11), 2300124.
    https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202300124
  6. Marple, April ST, Alexander H. Jesmer, Ben Lake, Anthony Rullo, and Ryan G. Wylie A Modular Antibody‐Oligomer T Cell Engager for Applications in Local Therapies. Advanced Therapeutics. 2023
    https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202300124
  7. Wilson, J., Kimmel, B., Arora, K., Chada, N., Bharti, V., Kwiatkowski, A., ... & Hargrove-Wiley, E. (2024). Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy. Research Square.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100900/
  8. 明 千葉, 拓也 松本, 健一郎 伊藤, 慧 山田, 吉彦 松田, 一敏 ▲高▼橋, 浩輝 山口, 友博 藤井, 慎介 清川, 豊 松田. Fc-CELL COMPLEX AND METHOD FOR PRODUCING THE SAME. (WO2025121429A1)
    https://patents.google.com/patent/WO2025121429A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=5