MC-Val-Cit-PAB-PNP

MC-Val-Cit-PAB-PNP

MC-Val-Cit-PAB-PNP is a cleavable ADC linker which contains a maleimide, a valine-citrulline (Val-Cit dipeptide, and a para-nitrophenyl (PNP) group. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP carbonate acts as a highly activated leaving group which may be used to react with amines. Val-Cit linkers are cleaved by Cathepsin B.

Molecular structure of the compound BP-23292
    • Unit
    • Price
    • Qty
    • 250 MG
    • $150.00
    • 500 MG
    • $260.00
    • 1 G
    • $450.00
    • 5 G
    • $1600.00

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Product Citations

  1. Cochran, M., Arias, D., Burke, R., Chu, D., Erdogan, G., Hood, M., ... & Doppalapudi, V. R. (2024). Structure–Activity Relationship of Antibody–Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody–siRNA Conjugates for Drug Development. Journal of medicinal chemistry.
    https://doi.org/10.1021/acs.jmedchem.4c00802