Mal-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate which contains a maleimide, a hydrophilic PEG spacer, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) spacer. Maleimide is a thiol-specific functional group which is used to label cysteine residues in proteins. Val-Cit-PAB linkers are cleaved by cytoplasmic peptidases.
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