Methyltetrazine-NHS ester

Methyltetrazine-NHS ester

Methyltetrazine-NHS Ester is a NHS actived building block containing a methyltetrazine group. It can react with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene). Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-22429
    • Unit
    • Price
    • Qty
    • 25 MG
    • $150.00
    • 100 MG
    • $287.00
    • 500 MG
    • $719.00
    • 1 G
    • $1352.00

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Product Citations

  1. Alshehri, S., Rawat, P., Basiri, A., Zhang, W., Fan, W., Rikhtechi, P., & Garrison, J. C. (2023). Exploration of a Pretargeted Theranostic Copolymer Employing Inverse Electron-Demand Diels–Alder Conjugation in Ovarian Cancer. ACS Applied Polymer Materials, 6(1), 218-231.
    https://pubs.acs.org/doi/abs/10.1021/acsapm.3c01849
  2. Hu, H., & Zhang, C. (2025). Conjugation of Multiple Proteins Onto the Surface of PLGA/Lipid Hybrid Nanoparticles. Journal of Biomedical Materials Research Part A, 113(1), e37807.
    https://doi.org/10.1002/jbm.a.37807
  3. Sang Jeon Chung, Yeong Soo Oh, Juhwan Kim, Sunmin Lee, Taejin Lee, Younggeun LEE, Jinwoo SEO, Geonmin LEE, Jinyoung SON. Method for increasing production yield of antibody-drug conjugate by using thiol-reactive additive. (EP4488290A1)
    https://patents.google.com/patent/EP4488290A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=25
  4. Sang Jeon Chung, Yeong Soo Oh, Juhwan Kim, Younggeun LEE, Jinwoo SEO, Geonmin LEE, Gahyeon KIM, Sejeong Kwon, Sunhee Park, Hojin YEOM, Hui Jo OH, Jinyoung SON. Antibody-drug conjugate comprising anti-claudin-18.2 antibody, and therapeutic use thereof for cancer. (EP4613291A1)
    https://patents.google.com/patent/EP4613291A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=17