TCO-PEG4-acid

TCO-PEG4-acid

TCO-PEG4-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. , TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-22420
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    • Price
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    • 25 MG
    • $276.00
    • 100 MG
    • $681.00
    • 500 MG
    • $2379.00

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Product Citations

  1. Adel Mahmoud ELSOHLY, Patrick Gwynn Holder. Systems and methods for tyrosinase-mediated site-specific protein conjugation. (US20230192760A1)
    https://patents.google.com/patent/US20230192760A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=28
  2. Holder P, ElSohly AM Reaction Landsape and Bioconjugation Profile of Tyrosinase Generated Quinones. ChemRXiv. 2018
    https://chemrxiv.org/engage/chemrxiv/article-details/60c74b2eee301c2d46c79db7
  3. Holder P, ElSohly AM. Reaction Landsape and Bioconjugation Profile of Tyrosinase Generated Quinones. ChemRXiv. 2020.
    https://chemrxiv.org/engage/chemrxiv/article-details/60c74b2eee301c2d46c79db9