MC-Val-Cit-PAB-MMAF

MC-Val-Cit-PAB-MMAF

MC-Val-Cit-PAB-MMAF is a precursor of antibody drug conjugates (ADCs) with an enzymatically cleavable VAl-Cit site. The maleimide group is reactive with thiol bearing molecules. MMAF is a synthetic antineoplastic agent which may be employed as a cytotoxic payload. The Val-Cit will specifically be cleaved by Cathepsin B.

Molecular structure of the compound BP-27843
    • Unit
    • Price
    • Qty
    • 5 MG
    • $210.00
    • 10 MG
    • $380.00
    • 25 MG
    • $650.00
    • 50 MG
    • $980.00

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Product Citations

  1. Pistono, P. E., Xu, J., Huang, P., Fetzer, J. L., & Francis, M. B. (2024). Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and Stability. Biochemistry, 63(15), 1913-1924.
    https://doi.org/10.1021/acs.biochem.4c00225