MC-Val-Cit-PAB-MMAF
MC-Val-Cit-PAB-MMAF is a precursor of antibody drug conjugates (ADCs) with an enzymatically cleavable VAl-Cit site. The maleimide group is reactive with thiol bearing molecules. MMAF is a synthetic antineoplastic agent which may be employed as a cytotoxic payload. The Val-Cit will specifically be cleaved by Cathepsin B.

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Catalog:
BP-27843
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Name:
MC-Val-Cit-PAB-MMAF
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Formula:
C68H103N11O16
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MW:
1330.6
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CAS:
863971-17-9
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Purity:
-
Ships Within:
24 Hours
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Storage Condition:
-20°C
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Solubility:
DMSO, DMF
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
View
Product Citations
- Pistono, P. E., Xu, J., Huang, P., Fetzer, J. L., & Francis, M. B. (2024). Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and Stability. Biochemistry, 63(15), 1913-1924.
https://doi.org/10.1021/acs.biochem.4c00225