ALC-0159
ALC-0159 is a PEG lipid molecule (i.e. PEGylated lipid), It is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). ALC-0159 is a non-ionic surfactant by its nature and It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran. Reagent grade, for research use only.

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Catalog:
BP-25711
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Name:
ALC-0159
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Formula:
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MW:
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CAS:
1849616-42-7
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Purity:
95%
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
View
Product Citations
- Hussain, M., Ferguson-Ugorenko, A., Macfarlane, R., Orr, N., Clarke, S., Wilkinson, M. J., ... & Perrie, Y. (2025). Mind the age gap: expanding the age window for mRNA vaccine testing in mice. Vaccines, 13(4), 370.
https://www.mdpi.com/2076-393X/13/4/370 - Jalil, S., Keskinen, T., Juutila, J., Maldonado, R. S., Euro, L., Suomalainen, A., ... & Wartiovaara, K. (2024). Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors. The American Journal of Human Genetics, 111(4), 714-728.
https://www.cell.com/ajhg/fulltext/S0002-9297(24)00077-6 - Kim, B., Seo, H. W., Lee, K., Yong, D., Park, Y. K., Lee, Y., ... & Ryu, C. M. (2024). Lipid Nanoparticle?Mediated CRISPR?Cas13a Delivery for the Control of Bacterial Infection. Advanced Healthcare Materials, 2403281.
https://doi.org/10.1002/adhm.202403281 - Lewis, M. M., Soto, M. R., Maier, E. Y., Wulfe, S. D., Bakheet, S., Obregon, H., & Ghosh, D. (2023). Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles. Bioengineering & Translational Medicine, e10580.
https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10580 - McMillan, C., Druschitz, A., Rumbelow, S., Borah, A., Binici, B., Rattray, Z., & Perrie, Y. (2024). Tailoring lipid nanoparticle dimensions through manufacturing processes. RSC pharmaceutics.
https://pubs.rsc.org/en/content/articlehtml/2024/pm/d4pm00128a