ALC-0159

ALC-0159

ALC-0159 is a PEG lipid molecule (i.e. PEGylated lipid), It is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). ALC-0159 is a non-ionic surfactant by its nature and It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran.

Molecular structure of the compound BP-25711
    • Unit
    • Price
    • Qty
    • 50 MG
    • $240.00
    • 100 MG
    • $430.00
    • 250 MG
    • $650.00
    • 500 MG
    • $980.00

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Product Citations

  1. Hussain, M., Ferguson-Ugorenko, A., Macfarlane, R., Orr, N., Clarke, S., Wilkinson, M. J., ... & Perrie, Y. (2025). Mind the age gap: expanding the age window for mRNA vaccine testing in mice. Vaccines, 13(4), 370.
    https://www.mdpi.com/2076-393X/13/4/370
  2. Jalil, S., Keskinen, T., Juutila, J., Maldonado, R. S., Euro, L., Suomalainen, A., ... & Wartiovaara, K. (2024). Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors. The American Journal of Human Genetics, 111(4), 714-728.
    https://www.cell.com/ajhg/fulltext/S0002-9297(24)00077-6
  3. Kim, B., Seo, H. W., Lee, K., Yong, D., Park, Y. K., Lee, Y., ... & Ryu, C. M. (2024). Lipid Nanoparticle?Mediated CRISPR?Cas13a Delivery for the Control of Bacterial Infection. Advanced Healthcare Materials, 2403281.
    https://doi.org/10.1002/adhm.202403281
  4. Lewis, M. M., Soto, M. R., Maier, E. Y., Wulfe, S. D., Bakheet, S., Obregon, H., & Ghosh, D. (2023). Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles. Bioengineering & Translational Medicine, e10580.
    https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10580
  5. McMillan, C., Druschitz, A., Rumbelow, S., Borah, A., Binici, B., Rattray, Z., & Perrie, Y. (2024). Tailoring lipid nanoparticle dimensions through manufacturing processes. RSC pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2024/pm/d4pm00128a