D-Lin-MC3-DMA

D-Lin-MC3-DMA

D-Lin-MC3-DMA (MC3) is a potent synthetic ionizable lipid. Its full name is (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate. D-Lin-MC3-DMA has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA, mRNA, DNA. The pKa is 6.44. Reagent grade, for research use only.

Molecular structure of the compound BP-25497
    • Unit
    • Price
    • Qty
    • 25 MG
    • $260.00
    • 50 MG
    • $450.00
    • 100 MG
    • $650.00
    • 250 MG
    • $980.00

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Product Citations

  1. Chiesa, E., Caimi, A., Bellotti, M., Giglio, A., Conti, B., Dorati, R., ... & Genta, I. (2024). Effect of Micromixer Design on Lipid Nanocarriers Manufacturing for the Delivery of Proteins and Nucleic Acids. Pharmaceutics, 16(4), 507.
    https://www.mdpi.com/1999-4923/16/4/507
  2. Omo-Lamai, S., Wang, Y., Patel, M. N., Essien, E. O., Shen, M., Majumder, A., ... & Brenner, J. S. (2024). Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects. bioRxiv, 2024-04.
    https://doi.org/10.1101/2024.04.16.589801
  3. Warminski, M., Depaix, A., Ziemkiewicz, K., Spiewla, T., Zuberek, J., Drazkowska, K., ... & Jemielity, J. (2024). Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents. Nucleic Acids Research, gkae763.
    https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae763/7753433