Amino-PEG4-Val-Cit-PAB-MMAE

Amino-PEG4-Val-Cit-PAB-MMAE

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Primary amines readily form amides with carboxylic acids in the presence of activator reagents such as HATU or EDC, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Molecular structure of the compound BP-24414
    • Unit
    • Price
    • Qty
    • 5 MG
    • $890.00
    • 10 MG
    • $1500.00
    • 25 MG
    • $2800.00

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Product Citations

  1. Zhang, Chaoyu, Wenjie Sheng, Marwah Al-Rawe, T. M. Mohiuddin, Marcus Niebert, Felix Zeppernick, Ivo Meihold-Heerlein, and Ahmad Fawzi Hussain.
    https://www.mdpi.com/1422-0067/23/11/6122/htm