TCO-PEG4-DBCO

TCO-PEG4-DBCO

TCO-PEG4-DBCO is a heterobifunctional click chemistry reagent containing a TCO and a DBCO moiety. TCO group specifically and efficiently reacts with terrahydrazine at fast speed. DBCO is very reactive toward Azide through copper free click chemistry, the PEG spacer increases the aqueous solubility of the reagent. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-24160
    • Unit
    • Price
    • Qty
    • 25 MG
    • $340.00
    • 50 MG
    • $550.00
    • 100 MG
    • $850.00
    • 250 MG
    • $1500.00

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Product Citations

  1. Mu, W., Chen, Y., Zhong, Z., Louage, B., Lauwers, H., Devoogdt, N., ... & De Geest, B. G. (2024). HER2 Nanobody-Poly (rhamnose) Conjugates Efficiently Recruit Anti-Rhamnose Antibodies from Serum to the Surface of HER2-Expressing Cells. Chemistry of Materials, 36(20), 10113-10124.
    https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.4c01500
  2. Rosato, Francesca, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi, and Winfried Römer A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death.. Research Square. 2022
    https://www.researchsquare.com/article/rs-2056554/latest.pdf