Bis-sulfone NHS Ester
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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Catalog:
BP-23344
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Name:
Bis-sulfone NHS Ester
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Formula:
C29H27NO9S2
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MW:
597.7
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CAS:
899452-51-8
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Purity:
90%
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
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Product Citations
- Chiang, W., Stout, A., Yanchik-Slade, F., Li, H., Terrando, N., Nilsson, B. L., ... & Krauss, T. D. (2023). Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation. ACS Applied Nano Materials, 6(16), 15094-15107.
https://pubs.acs.org/doi/epdf/10.1021/acsanm.3c02719