MC-Val-Cit-PAB-PNP
MC-Val-Cit-PAB-PNP is a cleavable ADC linker which contains a maleimide, a valine-citrulline (Val-Cit dipeptide, and a para-nitrophenyl (PNP) group. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP carbonate acts as a highly activated leaving group which may be used to react with amines. Val-Cit linkers are cleaved by Cathepsin B.

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Catalog:
BP-23292
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Name:
MC-Val-Cit-PAB-PNP
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Formula:
C35H43N7O11
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MW:
737.8
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CAS:
159857-81-5
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Purity:
96%
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
View
Product Citations
- Cochran, M., Arias, D., Burke, R., Chu, D., Erdogan, G., Hood, M., ... & Doppalapudi, V. R. (2024). Structure–Activity Relationship of Antibody–Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody–siRNA Conjugates for Drug Development. Journal of medicinal chemistry.
https://doi.org/10.1021/acs.jmedchem.4c00802