Mal-PEG8-Gly-Phe-Gly-Gly-DXD (Mal-PEG8-GGFG-DXD) is a specialized antibody-drug conjugate (ADC) linker-payload construct featuring a maleimide group for site-specific conjugation to antibodies or other cysteine-containing biomolecules. The PEG8 spacer enhances aqueous solubility and enables fine-tuning of drug metabolism and pharmacokinetic (DMPK) properties. The GGFG peptide sequence (Gly-Phe-Gly-Gly) serves as a protease-cleavable linker, allowing selective intracellular drug release upon enzymatic cleavage in the lysosomal environment.
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