GDC-0152 is a highly effective inhibitor of inhibitor of apoptosis proteins (IAPs). It specifically targets the BIR3 domains of XIAP, cIAP1, and cIAP2, as well as the BIR domain of ML-IAP, demonstrating strong binding affinity across these proteins. Its structural design enables precise interaction with these domains, highlighting its role in modulating IAP activity.
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