Antibody azido-PEG4-VA-PAB-SN38 Conjugation Kit, 1vial

This antibody Azido-PEG4-VA-PAB-SN38 Conjugation Kit is designed to conjugate 1 mg of antibody with the chemotherapeutic drug SN38 via copper-free click chemistry. The linker structure (shown below) is also composed of a cleavable val-ala dipeptide, which enhances drug molecule release to the cell. SN-38 is the active metabolite of the drug, Irinotecan, and its cytotoxic mechanism of action is through the inhibition of topoisomerase-I while it is bound to DNA cleavage complexes.