Antibody VC-PAB-SN-38 Conjugation Kit

BroadPharm's SN-38 Antibody Conjugation kit attaches the drug, SN-38 to antibody. The kit is designed to utilize the linker's maleimide group to react and attach to thiol groups on the antibody.

The linker- SN-38 is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11 ), and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.

Kit Features:
1. Protocol: easy to follow, to label IgG with SN38 with minimum exposure to the chemotherapeutic drug
2. Linkage: releasable linkage
3. Fast process: <1 h hands-on time, 6 h for whole process.
4. Convient: All reagents and supplies included for preparation purification, and storage
5. DAR: average 3-8
6. Efficient: More than 99% conjugated products by SEC and is free of any unreacted drugs