TCO-PEG4-acid
TCO-PEG4-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. , TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

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Catalog:
BP-22420
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Name:
TCO-PEG4-acid
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Formula:
C20H35NO8
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MW:
417.5
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CAS:
1802913-21-8
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Purity:
95%
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Solubility:
DMSO, DCM, DMF
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
View
Product Citations
- Holder P, ElSohly AM Reaction Landsape and Bioconjugation Profile of Tyrosinase Generated Quinones. ChemRXiv. 2018
https://chemrxiv.org/engage/chemrxiv/article-details/60c74b2eee301c2d46c79db7 - Holder P, ElSohly AM. Reaction Landsape and Bioconjugation Profile of Tyrosinase Generated Quinones. ChemRXiv. 2020.
https://chemrxiv.org/engage/chemrxiv/article-details/60c74b2eee301c2d46c79db9