DBCO-NHS

DBCO-NHS

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Please contact us for GMP-grade inquiries.

Molecular structure of the compound BP-22231
    • Unit
    • Price
    • Qty
    • 100 MG
    • $140.00
    • 250 MG
    • $350.00
    • 500 MG
    • $540.00
    • 1 G
    • $860.00

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Product Citations

  1. Bertucci, A., Capelli, L., Pedrini, F., Di Pede, A. C., Bagheri, N., Fortunati, S., ... & Porchetta, A. (2023). Synthetic Protein-to-DNA Input Exchange for Protease Activity Detection Using CRISPR-Cas12a.
    https://chemrxiv.org/engage/chemrxiv/article-details/6565bf5acf8b3c3cd74f4ffb
  2. Hu, H., & Zhang, C. (2025). Conjugation of Multiple Proteins Onto the Surface of PLGA/Lipid Hybrid Nanoparticles. Journal of Biomedical Materials Research Part A, 113(1), e37807.
    https://doi.org/10.1002/jbm.a.37807