N-(Azido-PEG4)-N-bis(PEG4-Val-Cit-PAB-MMAE) is a dual linker-payload containing an azide handle that is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The two linker-payloads each include the cathepsin-cleavable Val-Cit-PAB dipeptide ligated to an MMAE payload which is an efficiently released toxin to target cells to cause cellular apoptosis.
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