DBCO-N-bis(PEG8-acid) is a trifunctional molecule containing two carboxylic acids and a DBCO functional group. The DBCO is reactive towards azides in copper-free click chemistry while the carboxylic acids can be reacted with primary amines in the presence of a coupling reagent to form stable amide bonds. PEG linkers have higher aqueous solubility than their alkane counterparts, which may impact DMPK and ADME in vivo.
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